[Convention] Eurotau 2018ÉvénementCongrès

[Convention] Eurotau 2018

ChercheurDoctorant
Pôle événementiel
26/04/2018 - 09:00 - 27/04/2018 - 16:30

Next Thursday and Friday, “European scientists involved in Tau research meet in Lille to exchange new ideas and hypotheses on physiological and pathological roles of tau proteins”.1

More info.

Program

April 26, 2018

9:00

Welcome coffee - Poster setup

9:30

Introduction:  Luc Buée

9 :40

experimental models & atypical tau functions

9:40-10:00 Lefebvre B (France) DDX proteins: tau nuclear partners

10:00-10:20 Hanger D (UK) Animal and cell models of Tauopathy

10:20-10:40 Mudher A (UK) Wlds confers bystander protection against tau-mediated degeneration in a Drosophila model of tauopathy

10:40-11:00 Novak M/Smolek T (Slovakia) Humanized rat tau model for AD

11:00-11:20 Planel E (Canada) Regulation of tau by temperature

11:20-11:40 Mandelkow EM (Germany) Trans-neuronal transmission of Tau protein by exosomes

11:40-12:00 Takashima A (Japan) AMPA/NMDA stimulation causes somato dendritic localization of pTau protein: local translation of tau in dendrite

 

12 :00

Lunch and Poster session

13:30

Tau pathology

Milutinovic M (Quanterix) Simoa: Ultrasensitive immuno-assays for detection of tau and CNS biomarkers in serum & plasma

13:45-14:00 Verelst J (Belgium) A new panel of novel Tau monoclonal antibodies, rendering new insights in Tau structure and diagnosis

14:00-14:20 Ando K, Brion JP (Belgium) Alzheimer risk PICALM

14:20-14:40 Attems J (UK) Impact of cortical tau pathology on white matter integrity

14:40-15:00 Kovacs G (Austria) Astroglia and Tau: new perspectives

15:00-15:15 Hanseeuw B (Belgium) From amyloid and tau to cognitive decline: Serial PET measures …

15:15-15:30 Perrotin A (Piramal) 18F-PI-2620, clinical evaluation of a next generation tau PET agent in subjects with AD and PSP

15:30-15:45 Sanchez-Juan P (Spain) MAPT genetic variants and neurodegenerative diseases in Spanish population.

15:45-16:00 Caffrey TM (UK) MAPT genetic variations and neuronal maturity regulate alternatively-spliced exon expression

 

16:00

Coffee break and poster session

16:30

Tau dysfunctions and consequences

16:30-16:50 Medina M (Spain) Role of the N-terminal domain in tau secretion

16:50-17:10 Wegmann S (USA) Tau protein liquid-liquid phase separation: a novel way to initiate tau aggregation in the brain

17:10-17:30 Sotiropoulos I (Portugal) Endolysosomal sorting and degra-dation of tau and its role in glucocorticoid-driven hippocampal malfunction

17:30-17:50 Scheper W (NL) The UPR and tau pathology

17:50-18:05 Evans L (UK) Internalization and vesicular trafficking of tau in human forebrain neurons

18:05-18:20 Lastres-Becker I (Spain) Impaired signaling of transcription factors NF-kB and NRF2 in CX3CR1-deficient microglia leads to altered neuroinflammation and phagocytosis: implications in Tauopathies

18:20-18:35 Di Primio C (Italy) Behing the nuclear envelop: tau involved in gene regulation

 

 

April 27, 2018

8:30

Tau functions and therapeutics

8:30- 8:50 Zilka N (Axon Neuroscience) Let’s target disease tau and keep normal tau alive

8:50- 9:10 Courade JP (UCB Pharma) Tau antibodies are not born equal: epitope determine efficacy.

9:10- 9:30 Gozes I (Israel) Overexpression of recombinant ADNP significantly enhances microtubule dynamics: implication for the ADNP syndrome and neurodegenerative tauopathies

9:30- 9:45 Papanikolopoulou K (Greece) Altered proteostasis and neuroplasticity upon tau loss in Drosophila

9:45-10:00 Ching-Pang Chang (Taiwan) Beneficial effects of an adenosine augmentation compound (J4) in a mouse model of tauopathy

10:00-10:15 Melnyk P (France) New piperazine multi-action drugs prevent neurofibrillary degeneration and amyloid deposition, and improve memory in AD animal models

 

10:15

Coffee break

10:45

Structure & functions

10:45-11:05 Goedert M (UK) The cores of tau filaments

11:05-11:25 Serpell L (UK) Getting to the core of PHF

11:25-11:45 Margittai M (USA) To grow or not to grow: Tau fibril structure at the crossroads of seeding

11:45-12:05 Brandt R (Germany) Tau in the axon: Kiss-and-hop with microtubules and on the leash of annexins

12:05-12:25 Uytterhoeven V (Belgium) Reduction of Tau-synaptic vesicle associations alleviates presynaptic dysfunction

12:25-12:45 de Silva R (UK) MAPT-AS1, an antisense long non-coding RNA gene is a translational repressor of tau gene expression

 

12:45

Lunch & Poster session

14:00

Tau functions and dysfunctions

14:00-14:15 Devred F (France) Temperature-dependent reversible oligomerization of tau

14:15-14:30 Giustiniani J (France) FKBP52 decrease in neurons modulates autophagy and tau secretion

14:30-14:45 Smet-Nocca C (France) Identification of the phosphorylation pattern that drives tau aggregation

14:45-15:15 Flash-talks of selected posters

P3,P28,P40,P48,P52,P58

15:15-15:30 Awards

 

15:30

Informal discussion & poster session

16:30

Closing of the meeting

Sources

1 Alzheimer & Taupathies, “EUROTAU 2018”,  < http://lucbuee.fr/crbst_24.html >, consulté le 25/04/2018